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Missing heritability problem
The "missing heritability" problem can be defined as the fact that single genetic variations cannot account for much of the heritability of diseases, behaviors, and other phenotypes. This is a problem that has significant implications for medicine, since a person's susceptibility to disease may depend more on "the combined effect of all the genes in the background than on the disease genes in the foreground".
A model has been introduced that takes into account epigenetic inheritance on the risk and recurrence risk of a complex disease.〔
The limiting pathway (LP) model has been introduced in which a trait depends on the value of ''k'' inputs that can have rate limitations due to stoichiometric ratios, reactants required in a biochemical pathway, or proteins required for transcription of a gene. Each of these ''k'' inputs is a strictly additive trait that depends on a set of common or rare variants. When ''k'' = 1, the LP model is simply a standard additive trait.〔
The missing heritability is only missing if the reason for the heritability of a trait across many cultures/ecologies or geographic regions is the same, that is, only if the same alleles are effecting the observed heritability. However high and however consistent the heritability the genes behind it (the genes effecting it) may vary with the population.
==References==
抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』
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